Selective PPAR agonist treatment increases skeletal muscle lipid metabolism without altering mitochondrial energy coupling: an in vivo magnetic resonance spectroscopy study
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چکیده
Beat M. Jucker, Dewen Yang, Warren M. Casey, Alan R. Olzinski, Carolyn Williams, Stephen C. Lenhard, Jeffrey J. Legos, C. Terrance Hawk, Susanta K. Sarkar, and Stephen J. Newsholme Cardiovascular and Urogenital Center of Excellence for Drug Discovery, Laboratory of Animal Sciences, High Throughput Biology, Pre-Clinical Development, and Technology Development, GlaxoSmithKline, King of Prussia, Pennsylvania
منابع مشابه
Selective PPARdelta agonist treatment increases skeletal muscle lipid metabolism without altering mitochondrial energy coupling: an in vivo magnetic resonance spectroscopy study.
Peroxisome proliferator-activated receptor-delta (PPARdelta) activation results in upregulation of genes associated with skeletal muscle fatty acid oxidation and mitochondrial uncoupling. However, direct, noninvasive assessment of lipid metabolism and mitochondrial energy coupling in skeletal muscle following PPARdelta stimulation has not been examined. Therefore, in this study we examined the ...
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Lipid homeostasis is controlled by the peroxisome proliferator-activated receptors (PPARalpha, -beta/delta, and -gamma) that function as fatty acid-dependent DNA-binding proteins that regulate lipid metabolism. In vitro and in vivo genetic and pharmacological studies have demonstrated PPARalpha regulates lipid catabolism. In contrast, PPARgamma regulates the conflicting process of lipid storage...
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تاریخ انتشار 2007